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活动量决定食品摄入量

By a simple food-in/energy-out model, a run on the treadmill or swim in the pool should make you want to eat more.

But recent findings have suggested that exercise can actually help to slow overeating.

And a new study presents evidence that the body's physiologic response to-exercise can help re tune

the nervous system's cues and make the body feel less hungry, Rather more so.

Hunger is a complex sensation, but it is determined in part by neurons located in them, which send

signals to the brain telling it that you're either hungry or sated.Those neurons get their message from

hormones, including insulin and l. When the body develops a resistance to these messengers, people

become more prone to overeating weight gain. And scientists have begun to suspect that cellular

inflammation might be at partly responsible for allowing these signals to get out of whack.

Researchers behind the new work found that "physical activity reorganizes the set point of balance through

anti-inflammatory signaling," they reported in their paper,  online August 24 in PL Biology.

The key to the signaling seemed to be interleukin-6 (IL-6) and IL-10, which are ed by immune cells.

The compound IL6 gets released from muscles when they cont has been found to "play a central role

in the regulation of appetite, energy body composition," the researchers noted. But just how these

compounds might be acting the nervous system's components, such as the hypothalamus, remained murky.

To further explore this association, the Brazil-based research team examined energy use both lean and obese rats that swam or ran on a treadmill.

After the exercise, both the lean and obese rats had lower insulin levels, but the rats that had

been fed to become obese wen to eating more like their lean peers. By sampling the biological

profiles of some of ls, the scientists found that the exercise had changed the obese rats' ,

which included boosting IL-6. Rats that were given an antibody to inhibit

IL-6before exercise did not show the same biochemical or feeding patterns afterward.

"These molecules were crucial for increasing the sensitivity of the most important

hormones, insulin and l, which control appetite," Jo Car, of the Department

of Medicine at the State University of Campinas in So lo and coauthor of the new, said in a prepared statement.

Although the intense bursts of exercise seemed to spur these noticeable shifts

in chem, in this study the activity only reduced the food intake in rats that were already obese,

and the activity did not seem to directly relate to immediately apparent weight loss.

But this change alone suggests that physical activity "could help to reorganize the set point

nutritional balance and, therefore, aid in counteracting the energy imbalance induced by-related obesity,"

Car and his colleagues noted in the study.

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